Antimicrobial activities of Tephrosia vogelii against selected pathogenic fungi and bacteria strains

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dc.contributor.authorMlozi, Stephano H.
dc.contributor.authorMmongoyo, Juma A.
dc.contributor.authorChacha, Musa
dc.date.accessioned2021-04-27T13:37:20Z
dc.date.available2021-04-27T13:37:20Z
dc.date.issued2019-12-19
dc.description.abstractCandida albicans and Cryptococcus neoformans are dangerous pathogens causing fungal dis eases. C. albicans and C. neoformans developed resistance to fungicides such as fluconazole. Similarly, pathogenic bacteria Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Salmonella typhi have become resistant to antibiotcs such as methicillin. Thus, searching for alternative antimicrobial agents is inevitable. Tephrosia vogelii used traditionally for manage ment of fungal and bacterial diseases is potential source of antimicrobial agents. It is in this vein that, antimicrobial activities of leaf and root extracts of T. vogelii were evaluated against C. albicans (ATCC 90028), C. neoformans (clinical isolate), S. aureus (ATCC25923), E. coli (ATCC29953), K. pneumoniae (ATCC 700603) and S. typhi (NCTC 8385). A two-fold serial dilution method using the sterilised 96 wells of polystyrene microlitre plates used to determine the minimum inhibitory concentration (MIC) of extracts. Hexane and dichloromethane extracts exhibited the lowest activity against fungi strains with MICs >10 mg/mL. Root and leaf methanolic extracts exhibited activity at MICs of 5 and 1.25 mg/mL, respectively, against both tested fungi. Dichloromethane and methanolic extracts exhibited antibacterial activity with MICs ranging from 2.5 - 10 mg/mL and 0.625 - 5 mg/mL, respectively. Antimicrobial activities of the extracts of T. vogelii revealed potentiality of bioactives against fungal and bacterial diseases.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5682
dc.subjectTephrosia vogelii; antifungal agents; antibacterial agents; methanolic extractsen_US
dc.titleAntimicrobial activities of Tephrosia vogelii against selected pathogenic fungi and bacteria strainsen_US
dc.typeJournal Article, Peer Revieweden_US
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