Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of Uvaria pandensis
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Date
2021-11-21
Journal Title
Journal ISSN
Volume Title
Publisher
ACS
Abstract
Five new cyclohexene derivatives, dipandensin A and B (1 and 2) and pandensenols A–C (3–5), and 16 known secondary metabolites (6–21) were isolated from the methanol-soluble extracts of the stem and root barks of Uvaria pandensis. The structures were characterized by NMR spectroscopic and mass spectrometric analyses, and that of 6-methoxyzeylenol (6) was further confirmed by single-crystal X-ray crystallography, which also established its absolute configuration. The isolated metabolites were evaluated for antibacterial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis and the Gram-negative bacteria Enterococcus raffinosus, Escherichia coli, Paraburkholderia caledonica, Pectobacterium carotovorum, and Pseudomonas putida, as well as for cytotoxicity against the MCF-7 human breast cancer cell line. A mixture of uvaretin (20) and isouvaretin (21) exhibited significant antibacterial activity against B. subtilis (EC50 8.7 μM) and S. epidermidis (IC50 7.9 μM). (8′α,9′β-Dihydroxy)-3-farnesylindole (12) showed strong inhibitory activity (EC50 9.8 μM) against B. subtilis, comparable to the clinical reference ampicillin (EC50 17.9 μM). None of the compounds showed relevant cytotoxicity against the MCF-7 human breast cancer cell line.
Description
Keywords
Cyclohexene Derivatives
Citation
Gasper Maeda, Pieter J. Gilissen, Anastasia Rudenko, Jelle van der Wal, Catarina Bourgard, Arvind Kumar Gupta, Per Sunnerhagen, Joan J. E. Munissi, Stephen S. Nyandoro, and Máté Erdélyi. Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of Uvaria pandensis. J. Nat. Prod. 2021, 84(12), 3080−3089. https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.1c00811