Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of Uvaria pandensis

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dc.contributor.authorGasper, Maeda
dc.contributor.authorPieter, J. Gilissen
dc.contributor.authorAnastasia, Rudenko
dc.contributor.authorJelle, van der Wal,
dc.contributor.authorCatarina, Bourgard
dc.contributor.authorArvind, Kumar Gupta
dc.contributor.authorPer, Sunnerhagen
dc.contributor.authorJoan, J. E. Munissi
dc.contributor.authorStephen, S. Nyandoro
dc.contributor.authorMáté, Erdélyi
dc.date.accessioned2024-06-19T22:14:04Z
dc.date.available2024-06-19T22:14:04Z
dc.date.issued2021-11-21
dc.description.abstractFive new cyclohexene derivatives, dipandensin A and B (1 and 2) and pandensenols A–C (3–5), and 16 known secondary metabolites (6–21) were isolated from the methanol-soluble extracts of the stem and root barks of Uvaria pandensis. The structures were characterized by NMR spectroscopic and mass spectrometric analyses, and that of 6-methoxyzeylenol (6) was further confirmed by single-crystal X-ray crystallography, which also established its absolute configuration. The isolated metabolites were evaluated for antibacterial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis and the Gram-negative bacteria Enterococcus raffinosus, Escherichia coli, Paraburkholderia caledonica, Pectobacterium carotovorum, and Pseudomonas putida, as well as for cytotoxicity against the MCF-7 human breast cancer cell line. A mixture of uvaretin (20) and isouvaretin (21) exhibited significant antibacterial activity against B. subtilis (EC50 8.7 μM) and S. epidermidis (IC50 7.9 μM). (8′α,9′β-Dihydroxy)-3-farnesylindole (12) showed strong inhibitory activity (EC50 9.8 μM) against B. subtilis, comparable to the clinical reference ampicillin (EC50 17.9 μM). None of the compounds showed relevant cytotoxicity against the MCF-7 human breast cancer cell line.en_US
dc.description.sponsorshipSwedish Research Councilen_US
dc.identifier.citationGasper Maeda, Pieter J. Gilissen, Anastasia Rudenko, Jelle van der Wal, Catarina Bourgard, Arvind Kumar Gupta, Per Sunnerhagen, Joan J. E. Munissi, Stephen S. Nyandoro, and Máté Erdélyi. Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of Uvaria pandensis. J. Nat. Prod. 2021, 84(12), 3080−3089. https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.1c00811en_US
dc.identifier.urihttps://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.1c00811
dc.identifier.urihttps://repository.udsm.ac.tz/handle/123456789/6097
dc.publisherACSen_US
dc.subjectCyclohexene Derivativesen_US
dc.titleOxygenated Cyclohexene Derivatives from the Stem and Root Barks of Uvaria pandensisen_US
dc.typeJournal Articleen_US
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