Antimycobaterial and antibacterial activities of extracts from Caesalpinia bonduc ( L .) Roxb

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dc.contributor.authorMlozi, Stephano Hanolo
dc.date.accessioned2020-05-22T09:18:05Z
dc.date.available2020-05-22T09:18:05Z
dc.date.issued2017
dc.description.abstractAim of study: The study focused on searching bioactives that can be used to combat pathogenic microbes from leaves, stem wood and stem bark of Caesalpinia bonduc Roxb. Background: Many pathogenic microbes have developed resistance to most of the recommended first line and second line drugs. Antimicrobial resistances endanger the control of infectious diseases by increasing morbidity and mortality and impose massive costs on societies in both developed and developing countries. Medicinal plants used for treatment of infectious diseases are potential of bioactives to combat this problem. Caesalpinia bonduc (L.) Roxb is ethnomedically used by communities in Africa and India but little is known on the bioactive compounds therefrom. In order to know the bioactive on other parts of this plant it contains, it was necessary to undertake phytochemical investigation and antimicrobial analysis of extracts. Material and Method: The plant materials of Caesalpinia bonduc were collected from Kisakasaka mangrove reserve, Zanzibar. Micro-organisms were collected from Department of Microbiology at MUHAS. Methanol, chloroform and n-hexane extracts from stem wood, stem bark and leaves of Caesalpinia bonduc were evaluated for antimicrobials. Antibacterial activity was evaluated against Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC29953) and Pseudomonas aeruginosa (ATCC25922). Antimycobacterial activity was performed against two non-pathogenic mycobacteria species namely Mycobacteria indicus pranii and Mycobacteria madagascariense. The two-fold serial dilution method was used to evaluate MIC for antimicrobial activities. Chromatographic techniques employed in sequential extractions. Results: Extracts with high activity had MIC of 2.5 mg/mL while extracts with low activity had MIC of 5.0 mg/mL. Conclusion: Antimicrobial activity exhibited by extracts indicated that, Caesalpinia bonduc is a potential for bioactive metabolites which can be used as leads for the development of antimicrobial agents.en_US
dc.description.sponsorshipWIO-RISEen_US
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5454
dc.subjectCaesalpinia bonduc, antibacterial, antimycobacterialen_US
dc.titleAntimycobaterial and antibacterial activities of extracts from Caesalpinia bonduc ( L .) Roxben_US
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