Nanostructured Calcium Phosphates for Drug, Gene, DNA and Protein Delivery and as Anticancer Chemotherapeutic Devices

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dc.contributor.authorChoi, Andy H.
dc.contributor.authorMacha, Innocent J
dc.contributor.authorAkyol, Sibel
dc.contributor.authorCazalbou, Sophie
dc.contributor.authorBen-Nissan, Besim
dc.date.accessioned2019-02-15T19:56:08Z
dc.date.available2019-02-15T19:56:08Z
dc.date.issued2017-06-08
dc.description.abstractDuring the past two decades, a number of materials and devices have been utilised in drug delivery applications. A range of biomaterials with different morphologies and pore sizes are currently utilised. For any given biomaterial or bioceramic, having an adequate control of the chemical composition as well as the critical pore sizes is important in terms of controlling the effectiveness when used to deliver drugs locally. In comparison to all currently known and used biomaterials, given the fact that it possesses chemical similarity to human bone, and most importantly its dissolution characteristics which allow for bone regeneration and growth, calcium phosphate holds a special consideration. Moreover, due to their interconnected pore structure, marine materials such as shells and coral exoskeletons show potential for applications in drug delivery due to their easy conversion to calcium phosphates with controllable dissolution rates. This chapter covers a range of current methods used specifically for natural materials that can be converted to calcium phosphates and mixed with polymeric materials as thin film or nanostructured drug, genes, protein and range of delivery and as anticancer chemotherapeutic devices.en_US
dc.identifier.doidoi.org/10.1007/978-3-319-56059-5_6
dc.identifier.isbn978-3-319-56059-5
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5060
dc.language.isoenen_US
dc.subjectHydroxyapatite Foraminifera Marine material Coral skeleton Liposomes Surface modifications Biomimeticsen_US
dc.titleNanostructured Calcium Phosphates for Drug, Gene, DNA and Protein Delivery and as Anticancer Chemotherapeutic Devicesen_US
dc.typeBook chapteren_US
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