High fat diet worsens the adverse effects of antibiotic on intestinal health in juvenile Nile tilapia (Oreochromis niloticus).

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dc.contributor.authorSamwel Mchele Limbu
dc.contributor.authorMa, Qiang
dc.contributor.authorZhang, Mei-Ling
dc.contributor.authorDu, Zhen-Yu
dc.date.accessioned2021-04-17T17:37:49Z
dc.date.available2021-04-17T17:37:49Z
dc.date.issued2019-08-25
dc.description.abstractAntibiotics and high fat diets are commonly used independently in global aquaculture production for fish health management and to spare the use of costly protein as energy sources, respectively, causing relatively similar meta bolic effects and stresses. However, it is unknown whether dietary high fat worsens or attenuates the adverse effects caused by antibiotics in fish. We determined the ability of high fat diet to influence the adverse effects of oxytetra cycline on Nile tilapia, Oreochromis niloticus. Thirty Nile tilapia weighing 8.45 ± 0.15 g were fed on medium fat (MF; 70 g/kg) and high fat (HF; 120 g/kg) diets and the same fat levels supplemented with 2.00 g/kg diet of OTC (80 mg/kg body weight/day) hereafter, MFO and HFO for 65 days. The general growth performance, feed efficiency and intestinal health of fish were evaluated. The Nile tilapia fed on HFO diet had significantly lower growth rate, body protein content and feed efficiency compared to those fed on MFO diet. Dietary HFO affected the intestine histomorphology, which decreased dramatically the tight junction proteins of Nile tilapia and induced microbiota dysbiosis compared to MFO diet. The Nile tilapia fed on HFO diet had increased oxidative stress, which stimulated drug detoxification response, caused endoplasmic reticulum stress and apoptosis compared to those fed on MFO diet. The new findings from our study demonstrate that, the adverse effects of antibiotics in fish are different at me dium and high fat contents. Feeding fish with high fat diets with antibiotics worsen the adverse effects. This en lightens our understanding on the risks of antibiotics misuse and also suggests that antibiotics should be more strictly limited in aquaculture, in which high fat diets are currently widely used in fish production worldwide.en_US
dc.description.sponsorshipChinese government through Chinese Scholarship Council (CSC) and The Fundamental Research Funds for the Central Universities.en_US
dc.identifier.doihttps://doi.org/10.1016/j.scitotenv.2019.05.067
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5599
dc.publisherElsevieren_US
dc.subjectOxytetracyclineen_US
dc.subjectHigh fat diets with antibioticsen_US
dc.subjectMicrobiota dysbiosisen_US
dc.subjectOxidative stressen_US
dc.subjectEndoplasmic reticulum stressen_US
dc.subjectApoptosisen_US
dc.titleHigh fat diet worsens the adverse effects of antibiotic on intestinal health in juvenile Nile tilapia (Oreochromis niloticus).en_US
dc.typeJournal Article, Peer Revieweden_US
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