Iodine-Catalyzed Etherification of Morroniside

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dc.contributor.authorSunghwa, Fortunatus
dc.contributor.authorSakurai, Hiroaki
dc.contributor.authorSaiki, Ikuo
dc.contributor.authorKoketsu, Mamoru
dc.date.accessioned2016-07-21T18:26:16Z
dc.date.available2016-07-21T18:26:16Z
dc.date.issued2009-09
dc.descriptionFull text can be accessed at https://www.jstage.jst.go.jp/article/cpb/57/1/57_1_112/_pdfen_US
dc.description.abstractIn this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 μM.en_US
dc.identifier.citationSunghwa, F., Sakurai, H., Saiki, I. and Koketsu, M., 2009. Iodine-catalyzed etherification of morroniside. Chemical and Pharmaceutical Bulletin, 57(1), pp.112-115.en_US
dc.identifier.doi10.1002/chin.200936185
dc.identifier.urihttp://hdl.handle.net/20.500.11810/3371
dc.language.isoenen_US
dc.subjectetherificationen_US
dc.subjectMorronisideen_US
dc.subjectCytotoxicityen_US
dc.titleIodine-Catalyzed Etherification of Morronisideen_US
dc.typeJournal Articleen_US
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