Iodine-Catalyzed Etherification of Morroniside
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Date
2009-09
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Abstract
In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 μM.
Description
Full text can be accessed at
https://www.jstage.jst.go.jp/article/cpb/57/1/57_1_112/_pdf
Keywords
etherification, Morroniside, Cytotoxicity
Citation
Sunghwa, F., Sakurai, H., Saiki, I. and Koketsu, M., 2009. Iodine-catalyzed etherification of morroniside. Chemical and Pharmaceutical Bulletin, 57(1), pp.112-115.