Antifungal activity, Lycopersicon esculentum, fungal skin infection, bioactives

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dc.contributor.authorMlozi, Stephano Hanolo
dc.date.accessioned2020-05-22T09:36:56Z
dc.date.available2020-05-22T09:36:56Z
dc.date.issued2020
dc.description.abstractCandida albicans and Cryptococcus neoformans are dangerous pathogens causing fungal diseases. C. albicans and C. neoformans developed resistance to fungicides such as fluconazole. Similarly, pathogenic bacteria Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Salmonella typhi have become resistant to antibiotcs such as methicillin. Thus, searching for alternative antimicrobial agents is inevitable. Tephrosia vogelii used traditionally for management of fungal and bacterial diseases is potential source of antimicrobial agents. It is in this vein that, antimicrobial activities of leaf and root extracts of T. vogelii were evaluated against C. albicans (ATCC 90028), C. neoformans (clinical isolate), S. aureus (ATCC25923), E. coli (ATCC29953), K. pneumoniae (ATCC 700603) and S. typhi (NCTC 8385). A two-fold serial dilution method using the sterilised 96 wells of polystyrene microlitre plates used to determine the minimum inhibitory concentration (MIC) of extracts. Hexane and dichloromethane extracts exhibited the lowest activity against fungi strains with MICs >10 mg/mL. Root and leaf methanolic extracts exhibited activity at MICs of 5 and 1.25 mg/mL, respectively, against both tested fungi. Dichloromethane and methanolic extracts exhibited antibacterial activity with MICs ranging from 2.5 - 10 mg/mL and 0.625 - 5 mg/mL, respectively. Antimicrobial activities of the extracts of T. vogelii revealed potentiality of bioactives against fungal and bacterial diseases.en_US
dc.description.sponsorshipUDSM, MUCEen_US
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5456
dc.publisherTaylor and Francisen_US
dc.subjectTephrosia vogelii; antifungal agents; antibacterial agents; methanolic extractsen_US
dc.titleAntifungal activity, Lycopersicon esculentum, fungal skin infection, bioactivesen_US
dc.typeJournal Articleen_US
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