Total Synthesis of Ochnaflavone
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Date
2013
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Abstract
The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl
ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of
a diaryl ether and ring cyclization of an ether-linked dimeric chalcone to assemble the two flavone nuclei. Optimal experimental
conditions for the oxidative cyclization to form ochnaflavone were established.
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Keywords
biflavone, diaryl ether, natural products, nucleophilic aromatic substitution, ochnaflavone, tetrahydroochnaflavone