Morroniside cinnamic acid conjugate as an anti-inflammatory agent

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dc.contributor.authorTakeda, Yoshinori
dc.contributor.authorTanigawa, Naomi
dc.contributor.authorSunghwa, Fortunatus
dc.contributor.authorNinomiya, Masayuki
dc.contributor.authorHagiwara, Makoto
dc.contributor.authorMatsushita, Kenji
dc.contributor.authorKoketsu, Mamoru
dc.date.accessioned2016-07-21T18:18:07Z
dc.date.available2016-07-21T18:18:07Z
dc.date.issued2010-08
dc.descriptionFull text can be accessed at http://www.sciencedirect.com/science/article/pii/S0960894X10008693en_US
dc.description.abstractA morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC(50)=49.3 microM) by inhibiting the expression of E-selectin; further, it was more active than another cinnamic-acid-conjugated iridoid glycoside (harpagoside; IC(50)=88.2 microM), 7-O-methylmorroniside, and morroniside itself. As a result, 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of TNF-alpha-induced E-selectin expression.en_US
dc.identifier.citationTakeda, Y., Tanigawa, N., Sunghwa, F., Ninomiya, M., Hagiwara, M., Matsushita, K. and Koketsu, M., 2010. Morroniside cinnamic acid conjugate as an anti-inflammatory agent. Bioorganic & medicinal chemistry letters, 20(16), pp.4855-4857.en_US
dc.identifier.doi10.1016/j.bmcl.2010.06.095 · Source: PubMed
dc.identifier.urihttp://hdl.handle.net/20.500.11810/3367
dc.language.isoenen_US
dc.subjectMorronisideen_US
dc.subject7-O-Cinnamoylmorronisideen_US
dc.subjectAnti-inflammatory activityen_US
dc.titleMorroniside cinnamic acid conjugate as an anti-inflammatory agenten_US
dc.typeJournal Articleen_US
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