Morroniside cinnamic acid conjugate as an anti-inflammatory agent
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Date
2010-08
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Abstract
A morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC(50)=49.3 microM) by inhibiting the expression of E-selectin; further, it was more active than another cinnamic-acid-conjugated iridoid glycoside (harpagoside; IC(50)=88.2 microM), 7-O-methylmorroniside, and morroniside itself. As a result, 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of TNF-alpha-induced E-selectin expression.
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Full text can be accessed at
http://www.sciencedirect.com/science/article/pii/S0960894X10008693
Keywords
Morroniside, 7-O-Cinnamoylmorroniside, Anti-inflammatory activity
Citation
Takeda, Y., Tanigawa, N., Sunghwa, F., Ninomiya, M., Hagiwara, M., Matsushita, K. and Koketsu, M., 2010. Morroniside cinnamic acid conjugate as an anti-inflammatory agent. Bioorganic & medicinal chemistry letters, 20(16), pp.4855-4857.