Flavonoids from Erythrina Schliebenii
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Date
2017-01-23
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg mL–1 and 36.9–101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0–290.6 μM (pure compounds) and 38.3 to >100 μg mL–1 (crude extracts).
Description
Keywords
Flavonoids, Erythrina schliebenii
Citation
Flavonoids from Erythrina schliebenii Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, and Máté Erdélyi Journal of Natural Products 2017 80 (2), 377-383 DOI: 10.1021/acs.jnatprod.6b00839