N -Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis

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dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorNdanu, Joseph
dc.contributor.authorMunissi, Joan J. E.
dc.contributor.authorGruhonjic, Amra
dc.contributor.authorFitzpatrick, Paul A.
dc.contributor.authorLandberg, Göran
dc.contributor.authorLu, Yu
dc.contributor.authorWang, Bin
dc.contributor.authorPan, Fangfang
dc.contributor.authorRissanen, Kari
dc.contributor.authorErdélyi, Máté
dc.date.accessioned2016-06-26T17:09:03Z
dc.date.available2016-06-26T17:09:03Z
dc.date.issued2015-07
dc.description.abstractSeven N-cinnamoyltetraketides (1-7), including the new Z-toussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3-107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3-105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line.en_US
dc.identifier.citationNyandoro, S., Ndanu, J., Munissi, J., Gruhonjic, A., Fitzpatrick, P., & Landberg, G. et al. (2015). N -Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. J. Nat. Prod., 78(8), 2045-2050. http://dx.doi.org/10.1021/acs.jnatprod.5b00356en_US
dc.identifier.doi10.1021/acs.jnatprod.5b00356
dc.identifier.doihttp://dx.doi.org/10.1021/acs.jnatprod.5b00356
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2677
dc.language.isoenen_US
dc.publisherPubMeden_US
dc.subjectN -Cinnamoyltetraketideen_US
dc.subjectToussaintia orientalisen_US
dc.titleN -Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalisen_US
dc.typeJournal Article, Peer Revieweden_US
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