N -Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis

Seven N-cinnamoyltetraketides (1-7), including the new Z-toussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3-107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3-105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line.

Keywords

N -Cinnamoyltetraketide, Toussaintia orientalis

Citation

Nyandoro, S., Ndanu, J., Munissi, J., Gruhonjic, A., Fitzpatrick, P., & Landberg, G. et al. (2015). N -Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. J. Nat. Prod., 78(8), 2045-2050. http://dx.doi.org/10.1021/acs.jnatprod.5b00356

URI

http://hdl.handle.net/20.500.11810/2677

Collections

Chemistry Department

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