Ancistrotanzanine A, the First 5,3‘-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5,8‘-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis # ,1

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dc.contributor.authorBringmann, Gerhard
dc.contributor.authorDreyer, Michael
dc.contributor.authorFaber, Johan H.
dc.contributor.authorDalsgaard, Petur W.
dc.contributor.authorStaerk, Dan
dc.contributor.authorJaroszewski, Jerzy W.
dc.contributor.authorNdangalasi, Henry J.
dc.contributor.authorMbago, Frank M.
dc.contributor.authorBrun, Reto
dc.contributor.authorReichert, Matthias
dc.contributor.authorMaksimenka, Katja
dc.contributor.authorChristensen, Søren B.
dc.date.accessioned2016-07-08T12:17:32Z
dc.date.available2016-07-08T12:17:32Z
dc.date.issued2003-10
dc.descriptionFull text can be accessed at http://pubs.acs.org/doi/abs/10.1021/np030077ben_US
dc.description.abstractThe first phytochemical investigation of the recently discovered East African liana Ancistrocladus tanzaniensis is described, resulting in the isolation and structural elucidation of two new naphthylisoquinoline alkaloids, ancistrotanzanines A (5) and B (6), and the known compound ancistrotectoriline A (7). Ancistrotazanine A (5) represents a hitherto unprecedented 5,3'-coupling type between the naphthalene and isoquinoline portions, while 6 and 7 are 5,8'-coupled. The structures of the compounds were determined by spectroscopic, chemical, and chiroptical methods. Compounds 5 and 6 showed good activities against the pathogens of leishmaniasis and Chagas' disease, Leishmania donovani and Trypanosoma cruzi, while 5-7 displayed moderately potent antiplasmodial activities against Plasmodium falciparum parasites.en_US
dc.identifier.citationBringmann, G., Dreyer, M., Faber, J.H., Dalsgaard, P.W., Stærk, D., Jaroszewski, J.W., Ndangalasi, H., Mbago, F., Brun, R., Reichert, M. and Maksimenka, K., 2003. Ancistrotanzanine A, the First 5, 3'-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5, 8'-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis#, 1. Journal of natural products, 66(9), pp.1159-1165.en_US
dc.identifier.doi10.1021/np030077b · Source: PubMed
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2901
dc.language.isoenen_US
dc.titleAncistrotanzanine A, the First 5,3‘-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5,8‘-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis # ,1en_US
dc.typeJournal Articleen_US
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