Ancistrotanzanine A, the First 5,3‘-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5,8‘-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis # ,1
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2003-10
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Abstract
The first phytochemical investigation of the recently discovered East African liana Ancistrocladus tanzaniensis is described, resulting in the isolation and structural elucidation of two new naphthylisoquinoline alkaloids, ancistrotanzanines A (5) and B (6), and the known compound ancistrotectoriline A (7). Ancistrotazanine A (5) represents a hitherto unprecedented 5,3'-coupling type between the naphthalene and isoquinoline portions, while 6 and 7 are 5,8'-coupled. The structures of the compounds were determined by spectroscopic, chemical, and chiroptical methods. Compounds 5 and 6 showed good activities against the pathogens of leishmaniasis and Chagas' disease, Leishmania donovani and Trypanosoma cruzi, while 5-7 displayed moderately potent antiplasmodial activities against Plasmodium falciparum parasites.
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http://pubs.acs.org/doi/abs/10.1021/np030077b
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Bringmann, G., Dreyer, M., Faber, J.H., Dalsgaard, P.W., Stærk, D., Jaroszewski, J.W., Ndangalasi, H., Mbago, F., Brun, R., Reichert, M. and Maksimenka, K., 2003. Ancistrotanzanine A, the First 5, 3'-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5, 8'-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis#, 1. Journal of natural products, 66(9), pp.1159-1165.