Immune Protection against Virus Challenge in Aging Mice Is Not Affected By Latent Herpesviral Infections

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dc.contributor.authorMarandu, Thomas F.
dc.contributor.authorOduro, Jennifer D.
dc.contributor.authorBorkner, Lisa
dc.contributor.authorDekhtiarenko, Iryna
dc.contributor.authorUhrlaub, Jennifer
dc.contributor.authorDrabig, Anja
dc.contributor.authorKröger, Andrea
dc.contributor.authorZugich, Janko N.
dc.contributor.authorSain, Luka C.
dc.date.accessioned2016-07-08T07:23:54Z
dc.date.available2016-07-08T07:23:54Z
dc.date.issued2015-09
dc.description.abstractLatent herpesvirus infections alter the immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse CMV, HSV-1 and/or MHV-68 with Influenza, WNV or VSV. We observed no increase in mortality or weight-loss over herpesvirus-negative counterparts and a relative, but no absolute reduction in CD8 responses against acute infections. Therefore, herpesviruses do not appear to increase susceptibility to emerging infections in aging. Copyright © 2015, American Society for Microbiology. All Rights Reserveden_US
dc.identifier.citationMarandu, T.F., Oduro, J.D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J.L., Drabig, A., Kröger, A., Nikolich-Zugich, J. and Cicin-Sain, L., 2015. Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections. Journal of virology, 89(22), pp.11715-11717.en_US
dc.identifier.doi10.1128/JVI.01989-15 · Source: PubMed
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2837
dc.language.isoenen_US
dc.subjectImmune Protectionen_US
dc.subjectLatent Herpesviralen_US
dc.titleImmune Protection against Virus Challenge in Aging Mice Is Not Affected By Latent Herpesviral Infectionsen_US
dc.typeJournal Article, Peer Revieweden_US
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