Immune Protection against Virus Challenge in Aging Mice Is Not Affected By Latent Herpesviral Infections
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Date
2015-09
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Abstract
Latent herpesvirus infections alter the immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse CMV, HSV-1 and/or MHV-68 with Influenza, WNV or VSV. We observed no increase in mortality or weight-loss over herpesvirus-negative counterparts and a relative, but no absolute reduction in CD8 responses against acute infections. Therefore, herpesviruses do not appear to increase susceptibility to emerging infections in aging. Copyright © 2015, American Society for Microbiology. All Rights Reserved
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Keywords
Immune Protection, Latent Herpesviral
Citation
Marandu, T.F., Oduro, J.D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J.L., Drabig, A., Kröger, A., Nikolich-Zugich, J. and Cicin-Sain, L., 2015. Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections. Journal of virology, 89(22), pp.11715-11717.