Two New Pro-apoptotic Glucopyranosides from Tulbaghia Violacea

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dc.contributor.authorLyantagaye, Sylvester L.
dc.date.accessioned2016-05-05T14:08:35Z
dc.date.available2016-05-05T14:08:35Z
dc.date.issued2013
dc.description.abstractTulbaghia violacea is a widely known anticancer herb used as traditional medicine in the Southern African region. However, the identities of the chemical compounds responsible for the medicinal properties are still at large. Isolation of the pro-apoptotic compounds from T. violacea was carried out using apoptosis induction-guided fractionation. The chemical structures of the pro-apoptotic molecules were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR), infrared (IR) and elemental analysis. Pro-apoptotic glucopyranosides Dfructofuranose-(26)-methyl--D-glucoyranoside and -D-fructofuranosyl-(26)--D-glucopyranoside were uncovered from aqueous whole plant extracts of T. violacea using bioactivity-guided purification. Glucopyranosides D-fructofuranose-(26)-methyl--D-glucoyranoside and -D-fructofuranosyl-(26)- -D-glucopyranoside have structural similarity with the earlier reported methyl -D-glucopyranoside from the same herb, which selectively kills cancer cells through apoptosis mechanisms. The discovery of these molecules could contribute towards the development of new anticancer drugs.en_US
dc.identifier.citationLyantagaye, S.L., 2013. Two new pro-apoptotic glucopyranosides from Tulbaghia violacea. Journal of Medicinal Plants Research, 7(29), pp.2214-2220.en_US
dc.identifier.doi10.5897/JMPR2013.5140
dc.identifier.issn1996-0875 ©2013
dc.identifier.urihttp://hdl.handle.net/20.500.11810/1830
dc.language.isoenen_US
dc.subjectBioactivity-guided purificationen_US
dc.subjectGlucopyranosideen_US
dc.subjectPro-apoptoticen_US
dc.subjectTulbaghia violaceaen_US
dc.titleTwo New Pro-apoptotic Glucopyranosides from Tulbaghia Violaceaen_US
dc.typeJournal Article, Peer Revieweden_US
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