Synthesis of Polyamidoamine Dendrimer for Encapsulating Tetramethylscutellarein for Potential Bioactivity Enhancement

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dc.contributor.authorShadrack, Daniel M.
dc.contributor.authorMubofu, Egid B.
dc.contributor.authorNyandoro, Stephen S.
dc.date.accessioned2016-06-15T20:50:11Z
dc.date.available2016-06-15T20:50:11Z
dc.date.issued2015
dc.description.abstractThe biomedical potential of flavonoids is normally restricted by their low water solubility. However, little has been reported on their encapsulation into polyamidoamine (PAMAM) dendrimers to improve their biomedical applications. Generation four (G4) PAMAM dendrimer containing ethylenediaminetetraacetic acid core with acrylic acid and ethylenediamine as repeating units was synthesized by divergent approach and used to encapsulate a flavonoid tetramethylscutellarein (TMScu, 1) to study its solubility and in vitro release for potential bioactivity enhancement. The as-synthesized dendrimer and the dendrimer–TMScu complex were characterized by spectroscopic and spectrometric techniques. The encapsulation of 1 into dendrimer was achieved by a co-precipitation method with the encapsulation efficiency of 77.8% ± 0.69% and a loading capacity of 6.2% ± 0.06%. A phase solubility diagram indicated an increased water solubility of 1 as a function of dendrimer concentration at pH 4.0 and 7.2. In vitro release of 1 from its dendrimer complex indicated high percentage release at pH 4.0. The stability study of the TMScu-dendrimer at 0, 27 and 40 °C showed the formulations to be stable when stored in cool and dark conditions compared to those stored in light and warmer temperatures. Overall, PAMAM dendrimer-G4 is capable of encapsulating 1, increasing its solubility and thus could enhance its bioactivity.en_US
dc.identifier.citationShadrack, D.M., Mubofu, E.B. and Nyandoro, S.S., 2015. Synthesis of Polyamidoamine Dendrimer for Encapsulating Tetramethylscutellarein for Potential Bioactivity Enhancement. International journal of molecular sciences, 16(11), pp.26363-26377.en_US
dc.identifier.doi10.3390/ijms161125956
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2453
dc.language.isoenen_US
dc.subjectPAMAM G4 dendrimeren_US
dc.subjectEncapsulationen_US
dc.subjectTetramethylscutellareinen_US
dc.subjectSolubilizationen_US
dc.subjectIn vitro releaseen_US
dc.subjectStabilityen_US
dc.titleSynthesis of Polyamidoamine Dendrimer for Encapsulating Tetramethylscutellarein for Potential Bioactivity Enhancementen_US
dc.typeJournal Article, Peer Revieweden_US
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