A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts

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dc.contributor.authorChristopher, R.
dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorChacha, Musa
dc.contributor.authorde Koning, C. B.
dc.date.accessioned2016-06-26T17:08:52Z
dc.date.available2016-06-26T17:08:52Z
dc.date.issued2014-01-21
dc.descriptionFull text can be accessed at the following link http://www.tandfonline.com/doi/abs/10.1080/14786419.2013.863202en_US
dc.description.abstractA new cinnamolyglycoflavonoid 3-cinnamoyltribuloside (1), its precursor tribuloside and two known flavonoid glycosides afzelin and astilbin were isolated from Heritiera littoralis Dryand (Sterculiaceae) ethanolic leaf extract. The dichloromethane leaf extract afforded two known pentacyclic triterpenoids, 3β-taraxerol and friedelin. Extracts and compounds isolated therefrom, with the exception of 3β-taraxerol, exhibited antimycobacterial activity against the non-pathogenic Mycobacterium species Mycobacterium madagascariense and Mycobacterium indicus pranii, with a minimum inhibitory concentration (MIC) 5.0 mg/mL for the crude extracts and MICs in the range of 1.6-0.8 mg/mL for the pure compounds. The extracts together with 3-cinnamoyltribuloside (1), tribuloside and astilbin exhibited 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. The compounds that showed dual activities could be further evaluated under clinical settings for co-administration with standard anti-tuberculosis drugs. Data on the essential oil composition of Fissistigma villosissimum, Fissistigma latifolium and Fissistigma glaucescens are reported for the first time.en_US
dc.identifier.citationChristopher, R., Nyandoro, S., Chacha, M., & de Koning, C. (2014). A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts. Natural Product Research, 28(6), 351-358. http://dx.doi.org/10.1080/14786419.2013.863202en_US
dc.identifier.doi10.1080/14786419.2013.863202
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2673
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.titleA new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extractsen_US
dc.typeJournal Article, Peer Revieweden_US
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