Recombination, selection and clock-like evolution of Rice yellow mottle virus

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dc.contributor.authorGalzi, Agnès P.
dc.contributor.authorMpunami, Anatolia
dc.contributor.authorSangu, Emmanuel
dc.contributor.authorRakotomalala, Mbolarinosy
dc.contributor.authorTraore, Oumar
dc.contributor.authorSereme, Drissa
dc.contributor.authorFatogoma, Sorho
dc.contributor.authorSere, Y.
dc.contributor.authorKanyeka, Zakaria L.
dc.contributor.authorKonaté, Gnissa
dc.contributor.authorFargette, Denis
dc.date.accessioned2016-07-08T12:14:29Z
dc.date.available2016-07-08T12:14:29Z
dc.date.issued2009-09
dc.description.abstractThe clock-like diversification of Rice yellow mottle virus (RYMV), a widespread RNA plant virus that infects rice in Africa, was tested following a three-step approach with (i) an exhaustive search of recombinants, (ii) a comprehensive assessment of the selective constraints over lineages, and (iii) a stepwise series of tests of the molecular clock hypothesis. The first evidence of recombination in RYMV was found in East Africa, in the region most favorable to co-infection. RYMV evolved under a pronounced purifying selection, but the selection pressure did vary among lineages. There was no phylogenetic evidence of transient deleterious mutations. ORF2b, which codes for the polymerase and is the most constrained ORF, tends to diversify clock-like. With the other ORFs and the full genome, the departure from the strict clock model was limited. This likely reflects the dominant conservative selection pressure and the clock-like fixation of synonymous mutations.en_US
dc.identifier.citationPinel-Galzi, A., Mpunami, A., Sangu, E., Rakotomalala, M., Traoré, O., Sérémé, D., Sorho, F., Séré, Y., Kanyeka, Z., Konaté, G. and Fargette, D., 2009. Recombination, selection and clock-like evolution of Rice yellow mottle virus. Virology, 394(1), pp.164-172.en_US
dc.identifier.doi10.1016/j.virol.2009.08.008 · Source: PubMed
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2889
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectMolecular clocken_US
dc.subjectRecombinationen_US
dc.subjectSelection pressureen_US
dc.subjectPhylogeographyen_US
dc.titleRecombination, selection and clock-like evolution of Rice yellow mottle virusen_US
dc.typeJournal Article, Peer Revieweden_US
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