New antimicrobial, mosquito larvicidal and other metabolites from two Artabotrys species

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dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorJoseph, Cosam C.
dc.contributor.authorNkunya, Mayunga H. H.
dc.contributor.authorHosea, Ken M.
dc.date.accessioned2016-06-26T17:08:48Z
dc.date.available2016-06-26T17:08:48Z
dc.date.issued2012-09
dc.descriptionFull text can be accessed at the following link http://www.tandfonline.com/doi/abs/10.1080/14786419.2012.725397?journalCode=gnpl20en_US
dc.description.abstractAzabicycloheptenoylditerpene 1-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)-2-azabicyclo[2.2.1]hept-5-en-3-one (artamodamide, 1), diphenylpentanoid (E)-1,5-bis(4-hydroxyphenyl)-pent-1-en-3-one (artamenone, 2) and N-methoxy-5-oxoaporphinoid (artamonteirine, 3) were isolated as new metabolites from Artabotrys modestus Diels ssp macranthus Verdc. and Artabotrys monteiroae Oliv. (Annonaceae), together with several known compounds. Structures of the isolated compounds were established based on analysis of their spectroscopic data. Some of the compounds exhibited antimicrobial activity (minimum inhibitory concentration values between 2.5 and 20 µg mL−1) and varying levels of mosquito larvicidal potency. These results further indicate the versatility of the family Annonaceae in accumulating bioactive natural products with diverse chemical structures and wide spectra of biological activities, and hence suggesting the need to conserve Annonaceae species that are potentially vulnerable to extinction.en_US
dc.identifier.citationNyandoro, S., Joseph, C., Nkunya, M., & Hosea, K. (2013). New antimicrobial, mosquito larvicidal and other metabolites from two Artabotrys species. Natural Product Research, 27(16), 1450-1458. http://dx.doi.org/10.1080/14786419.2012.725397en_US
dc.identifier.doi10.1080/14786419.2012.725397
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2671
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectAnnonaceaeen_US
dc.subjectArtabotrys modestusen_US
dc.subjectArtabotrys monteiroaeen_US
dc.subjectAzabicycloheptenoylditerpeneen_US
dc.subjectdiphenylpentanoiden_US
dc.subjectN-methoxy-5-oxoaporphinoiden_US
dc.subjectAntimicrobialen_US
dc.subjectLarvicidalen_US
dc.titleNew antimicrobial, mosquito larvicidal and other metabolites from two Artabotrys speciesen_US
dc.typeJournal Article, Peer Revieweden_US
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