Cleistenolide and cleistodienol: Novel bioactive constituents of Cleistochlamys kirkii

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dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorMdachi, Stephen
dc.contributor.authorNkunya, Mayunga H. H.
dc.contributor.authorIrungu, Beatrice N.
dc.contributor.authorMoshi, Mainen
dc.contributor.authorMoulton, Brian
dc.contributor.authorLuisi, Brian S.
dc.date.accessioned2016-06-26T17:08:46Z
dc.date.available2016-06-26T17:08:46Z
dc.date.issued2007-01
dc.description.abstract(-)-5-Acetoxy-6-(1-benzoyloxy-2-acetoxyethyl)-pyr-3-en-2-one (cleistenolide) and (-)-2, 6-diacetoxy-5-hydroxy-cyclohex-3-enylidenemethyl benzoate (cleistodienol) were isolated as novel antimicrobial and cytotoxic constituents of Cleistochlamys kirkii (Annonaceae), together with (Z)-(+)-5-(2, 3-dihydroxy-propylidene)-5H-furan-2-one and its acetyl and benzoyl derivatives, (-)-1, 6-desoxy-β-senepoxide, pinocembrin and polycarpol. Structural determination was achieved based on spectroscopic and other physical data. The structure of cleistenolide was confirmed by single crystal X-ray crystallographic analysis.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2670
dc.language.isoenen_US
dc.titleCleistenolide and cleistodienol: Novel bioactive constituents of Cleistochlamys kirkiien_US
dc.typeOtheren_US
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