IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus).

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dc.contributor.authorCai-Zhi, Liu
dc.contributor.authorYuan, Luo
dc.contributor.authorSamwel Mchele Limbu
dc.contributor.authorLi-Qiao, Chen
dc.contributor.authorZhen-Yu, Du
dc.date.accessioned2019-05-07T13:05:51Z
dc.date.available2019-05-07T13:05:51Z
dc.date.issued2018-04-12
dc.description.abstractInsulin-like growth factor-1 (IGF-1) plays a crucial role in regulating growth in vertebrates while suppressors of cytokine signaling (SOCS) act as feedback inhibitors of the GH/IGF-1 axis. Although SOCS-2 binds IGF-1 receptor and inhibits IGF-1-induced STAT3 activation, presently there is no clear evidence whether IGF-1 could induce SOCS genes expression. The current study aimed to determine whether IGF-1 could induce the transcription of SOCS in juvenile Nile tilapia (Oreochromis niloticus). We show that there is a common positive relationship between the mRNA expression of IGF-I and SOCS-2 under different nutritional statuses and stimulants, but not the expression of SOCS-1 and SOCS-3 mRNA. Furthermore, rhIGF-1 treatment and transcriptional activity assay confirmed the hypothesis that IGF-1 could induce SOCS-2 expression, while has no effect or even decreased the expression of SOCS-1 and SOCS-3. Overall, we obtained evidence that the transcription of SOCS-2, but not SOCS-1 or SOCS-3 could be induced by IGF signaling, suggesting the SOCS-2 serves as a feedback suppressor of IGF-1 axis in juvenile Nile tilapia.en_US
dc.description.sponsorshipThe National Basic Research Program of China (973 program 2014CB138603) and National Natural Science Fund (31472290 and 31772859).en_US
dc.identifier.doihttp://jeb.biologists.org/content/early/2018/04/11/jeb.179291
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5222
dc.publisherThe Company of Biologists Limiteden_US
dc.subjectNile tilapia (Oreochromis niloticus)en_US
dc.subjectInsulin-like growth factoren_US
dc.subjectSuppressor of cytokine signalingen_US
dc.subjectTranscriptionen_US
dc.titleIGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus).en_US
dc.typeJournal Article, Peer Revieweden_US
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