Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis

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dc.contributor.authorAronsson, Per
dc.contributor.authorMunissi, Joan J. E.
dc.contributor.authorGruhonjic, Amra
dc.contributor.authorFitzpatrick, Paul A.
dc.contributor.authorLandberg, Göran
dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorErdélyi, Máté
dc.date.accessioned2016-06-26T17:09:05Z
dc.date.available2016-06-26T17:09:05Z
dc.date.issued2016-01-15
dc.description.abstractAs part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8′-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone (2) and cis-isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3′-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520–82.1 μM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 μg/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 μg/mL). The radical scavenging activity of the isolated constituents (1–5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.en_US
dc.identifier.citationAronsson, P., Munissi, J., Gruhonjic, A., Fitzpatrick, P., Landberg, G., Nyandoro, S., & Erdelyi, M. (2016). Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis. Diseases, 4(1), 3. http://dx.doi.org/10.3390/diseases4010003en_US
dc.identifier.doi10.3390/diseases4010003
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2678
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectDiospyros shimbaensisen_US
dc.subjectEbenaceaeen_US
dc.subjectTetralonesen_US
dc.subjectNaphthoquinoesen_US
dc.subjectRadical scavengingen_US
dc.subjectCytotoxicityen_US
dc.subjectMDA-MB-231en_US
dc.subjectDPPHen_US
dc.titlePhytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensisen_US
dc.typeJournal Article, Peer Revieweden_US
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