Atorvastatin remodels lipid distribution between liver and adipose tissues through blocking lipoprotein efflux in fish

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dc.contributor.authorRui-Xin Li
dc.contributor.authorLing-Yun Chen
dc.contributor.authorSamwel Mchele Limbu
dc.contributor.authorBing Yao
dc.contributor.authorYi-Fan Qian
dc.contributor.authorWen-Hao Zhou
dc.contributor.authorLi-Qiao Chen
dc.contributor.authorFang Qiao
dc.contributor.authorMei-Ling Zhang
dc.contributor.authorZhen-Yu Du
dc.contributor.authorYuan Luo
dc.date.accessioned2023-04-14T15:00:39Z
dc.date.available2023-04-14T15:00:39Z
dc.date.issued2023-03-01
dc.description.abstractThe regulation of cholesterol metabolism in fish is still unclear. Statins play important roles in promoting cholesterol metabolism development in mammals. However, studies on the role of statins in cholesterol metabolism in fish are currently limited. The present study evaluated the effects of statins on cholesterol metabolism in fish. Nile tilapia (Oreochromis niloticus) were fed on control diets supplemented with three atorvastatin levels (0, 12, and 24 mg/kg diet, ATV0, ATV12, and ATV24, respectively) for 4 wk. Intriguingly, the results showed that both atorvastatin treatments increased hepatic cholesterol and triglyceride contents mainly through inhibiting bile acid synthesis and efflux, and compensatorily enhancing cholesterol synthesis in fish liver (P < 0.05). Moreover, atorvastatin treatment significantly inhibited hepatic very-low-density lipoprotein (VLDL) assembly and thus decreased serum VLDL content (P < 0.05). However, fish treated with atorvastatin significantly reduced cholesterol and triglycerides contents in adipose tissue (P < 0.05). Further molecular analysis showed that atorvastatin treatment promoted cholesterol synthesis and lipogenesis pathways, but inhibited lipid catabolism and low-density lipoprotein (LDL) uptake in the adipose tissue of fish (P < 0.05). In general, atorvastatin induced the remodeling of lipid distribution between liver and adipose tissues through blocking VLDL efflux from the liver to adipose tissue of fish. Our results provide a novel regulatory pattern of cholesterol metabolism response caused by atorvastatin in fish, which is distinct from mammals: cholesterol inhibition by atorvastatin activates hepatic cholesterol synthesis and inhibits its efflux to maintain cholesterol homeostasis, consequently reduces cholesterol storage in fish adipose tissue.en_US
dc.description.sponsorshipNational Key R and D Program of China under Grant No. 2018YFD0900400en_US
dc.identifier.citationRui-Xin Li, Ling-Yun Chen, Samwel M. Limbu, Bing Yao, Yi-Fan Qian, Wen-Hao Zhou, Li-Qiao Chen, Fang Qiao, Mei-Ling Zhang, Zhen-Yu Du and Yuan Luo (2023). Atorvastatin remodels lipid distribution between liver and adipose tissues through blocking lipoprotein efflux in fish. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 324(3): R281-R292. https://doi.org/10.1152/ajpregu.00222.2022en_US
dc.identifier.doihttps://doi.org/10.1152/ajpregu.00222.2022
dc.identifier.urihttp://hdl.handle.net/20.500.11810/6035
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.subjectatorvastatinen_US
dc.subjectcholesterol metabolismen_US
dc.subjectlipid metabolismen_US
dc.subjectNile tilapiaen_US
dc.titleAtorvastatin remodels lipid distribution between liver and adipose tissues through blocking lipoprotein efflux in fishen_US
dc.typeJournal Article, Peer Revieweden_US
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