Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery

Simple item page
dc.contributor.authorMacha, Innocent J
dc.contributor.authorCazalbou, Sophie
dc.contributor.authorBen-Nissan, Besim
dc.contributor.authorHarvey, Kate
dc.contributor.authorMilthorpe, Bruce K.
dc.date.accessioned2016-06-21T10:13:17Z
dc.date.available2016-06-21T10:13:17Z
dc.date.issued2015-01
dc.description.abstractHydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by S. aureus in surgery.en_US
dc.identifier.citationMacha, I.J., Cazalbou, S., Ben-Nissan, B., Harvey, K.L. and Milthorpe, B., 2015. Marine structure derived calcium phosphate–polymer biocomposites for local antibiotic delivery. Marine drugs, 13(1), pp.666-680.en_US
dc.identifier.doi10.3390/md13010666
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2643
dc.language.isoenen_US
dc.subjectDrug releaseen_US
dc.subjectThin film compositesen_US
dc.subjectCoralen_US
dc.subjectHydroxyapatiteen_US
dc.subjectMicrobial adhesionen_US
dc.titleMarine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Deliveryen_US
dc.typeJournal Article, Peer Revieweden_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery.pdf
Size:
8.47 MB
Format:
Adobe Portable Document Format
Description:
Full text
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Department of Mechanical and Industrial Engineering