Ancistrotanzanine C and Related 5,1‘- And 7,3‘-Coupled Naphthylisoquinoline Alkaloids From Ancistrocladus T Anzaniensis 1

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dc.contributor.authorBringmann, Gerhard
dc.contributor.authorDreyer, Michael
dc.contributor.authorFaber, Johan H.
dc.contributor.authorDalsgaard, Petur W.
dc.contributor.authorStaerk, Dan
dc.contributor.authorJaroszewski, Jerzy W.
dc.contributor.authorNdangalasi, Henry J.
dc.contributor.authorMbago, Frank M.
dc.contributor.authorBrun, Reto
dc.contributor.authorChristensen, Søren B.
dc.date.accessioned2016-07-08T11:48:20Z
dc.date.available2016-07-08T11:48:20Z
dc.date.issued2004-05
dc.descriptionFull text can be accessed at http://pubs.acs.org/doi/abs/10.1021/np0340549en_US
dc.description.abstractThree new naphthylisoquinoline alkaloids, the 7,3'-coupled ancistrotanzanine C (6), the 5,1'-coupled O-methylancistrocladinine (7), and the likewise 5,1'-coupled O,N-dimethylancistrocladine (8, previously known only as a partial-synthetic compound), have been isolated from the highland liana Ancistrocladus tanzaniensis, along with the two known 7,3'-coupled naphthylisoquinoline alkaloids ancistrocladidine (4) and ancistrotectorine (5). All of the compounds are S-configured at C-3 and bear an oxygen at C-6, and thus belong to the so-called Ancistrocladaceae type, similar to 1-3 previously isolated from this newly discovered plant species. The structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. The biological activities of the alkaloids against the pathogens causing malaria tropica, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated.en_US
dc.identifier.citationBringmann, G., Dreyer, M., Faber, J.H., Dalsgaard, P.W., Stærk, D., Jaroszewski, J.W., Ndangalasi, H., Mbago, F., Brun, R. and Christensen, S.B., 2004. Ancistrotanzanine C and Related 5, 1'-and 7, 3'-Coupled Naphthylisoquinoline Alkaloids from Ancistrocladus t anzaniensis 1. Journal of natural products, 67(5), pp.743-748.en_US
dc.identifier.doi10.1021/np0340549 · Source: PubMed
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2842
dc.language.isoenen_US
dc.titleAncistrotanzanine C and Related 5,1‘- And 7,3‘-Coupled Naphthylisoquinoline Alkaloids From Ancistrocladus T Anzaniensis 1en_US
dc.typeJournal Articleen_US
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