The Influence of Aliphatic Side Chain of Anacardic Acid on Molecular Recognition Properties of Imprinted Polymers

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dc.contributor.authorPhilip, Joseph Y. N.
dc.contributor.authorBuchweishaija, Joseph
dc.contributor.authorMkayula, Lupituko L.
dc.date.accessioned2016-09-21T17:16:36Z
dc.date.available2016-09-21T17:16:36Z
dc.date.issued2012
dc.description.abstractThe objective of this work was to determine the influence of the aliphatic side chain of anacardic acid on molecular recognition properties of imprinted polymers made from anacardanyl methacrylate (AnMcr). Salicylic methacrylate (SaMcr), a structural analog of AnMcr, was synthesized and used as a functional monomer to prepare imprinted polymers for comparison with AnMcr-based polymers. Using divinylbenzene (DVB) as a cross linker and racemic propranolol as a model template, irregular monolithic particles of poly(SaMcr-co-DVB)m were synthesized in toluene, and spherical beads of poly(SaMcr-co-DVB)b and poly(AnMcr-co-DVB)b were synthesized in acetonitrile by precipitation polymerization. Although imprinted irregular monolithic particles, poly(SaMcr-co-DVB)m, tested in toluene containing 0.5% acetic acid, displayed relatively low specific propranolol binding, they showed high molecular selectivity. For the spherical beads tested in acetonitrile, both imprinted poly(AnMcr-co-DVB)b and poly(SaMcrco-DVB)b showed obvious specific propranolol binding despite the use of polar organic solvent during imprinting. Imprinted poly(AnMcr-co-DVB)b showed higher molecular selectivity than imprinted poly(SaMcr-co-DVB)b. Interestingly, the presence of the aliphatic side chain in AnMcr resulted in more uniform imprinted beads as compared to particle agglomerates obtained from SaMcr in the presence of propranolol template. Therefore, the aliphatic side chain of anacardic acid improves both molecular recognition of imprinted polymers as well as the formation of uniform imprinted spherical beads.en_US
dc.identifier.citationPhilip, J.Y.N., Buchweishaija, J., Mkayula, L.L. and Ye, L., 2012. The influence of aliphatic side chain of anacardic acid on molecular recognition properties of imprinted polymers. Tanzania Journal of Science, 38(1), pp.104-117.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.11810/4163
dc.language.isoenen_US
dc.subjectMolecular imprintingen_US
dc.subjectAnacardanyl methacrylateen_US
dc.subjectSalicylic methacrylateen_US
dc.subjectPropranololen_US
dc.subjectPrecipitation polymerizationen_US
dc.titleThe Influence of Aliphatic Side Chain of Anacardic Acid on Molecular Recognition Properties of Imprinted Polymersen_US
dc.typeJournal Article, Peer Revieweden_US
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