Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications

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dc.contributor.authorMacha, Innocent J
dc.contributor.authorKaracan, Ipek
dc.contributor.authorBen-Nissan, Besim
dc.contributor.authorCazalbou, Sophie
dc.contributor.authorMuller, Wolfgang H
dc.date.accessioned2019-02-14T20:18:54Z
dc.date.available2019-02-14T20:18:54Z
dc.date.issued2019-01
dc.description.abstractWhile one of the major clinical and scientific challenges in the management of implant-related infections and post- operative complications after surgery is the application of new techniques, a new approach is pertinent in the design of medical implants to reduce bacterial infections. We have designed and tested antibiotic-containing biocomposite thin films of polylactic acid (PLA), and coralline-derived hydroxyapatite (HAp) as controlled drug delivery systems for the treatment of dental, orthopaedic and neural implant-related post-operative infections. These films can be applied to complicated designs of dental, miniaturized neural devices, cochlear or total hip replacement (THR) implants by spray or dip-coating techniques. Current results reveal that the devices could release antibiotic in a controlled manner to prevent significantly bacterial growth and biofilm production. Hydroxyapatite within the composites controls the release rate and also supplies minerals, such as calcium Ca2+ and phosphate PO42− ions, which are essential minerals for bone tissue regeneration. It is concluded from the physical, mechanical and biological properties that these coatings and devices could easily be utilized in a wide range of biomedical applications.en_US
dc.identifier.doidoi.org/10.1007/s42452-018-0064-1
dc.identifier.issn2523-3971
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5046
dc.language.isoenen_US
dc.publisherSpringer NATUREen_US
dc.subjectImplant coating · Dental implant · Drug release · Antibiotic · Hydroxyapatite · Polymer composite · Biofilm · Post-operative infection · Cochlear devices · Neural devicesen_US
dc.titleDevelopment of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applicationsen_US
dc.typeJournal Articleen_US
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