Altered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in Tanzania

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dc.contributor.authorMbuya, Wilbert
dc.contributor.authorMwakyula, Issakwisa
dc.contributor.authorOlomi, Willyelimina
dc.contributor.authorAgrea, Peter
dc.contributor.authorNicoli, Francesco
dc.contributor.authorNgatunga, Cecilia
dc.contributor.authorMujwahuzi, Leodegard
dc.contributor.authorMwanyika, Paul
dc.contributor.authorChachage, Mkunde
dc.date.accessioned2022-11-23T15:38:59Z
dc.date.available2022-11-23T15:38:59Z
dc.date.issued2021-11-09
dc.description.abstractPeople living with HIV, even under therapy, have a high burden of age-related co-morbidities including an increased risk of dyslipidemia (which often predisposes to cardiovascular diseases) and immune-aging. In this study, lipid profiles and antibody responses to measles and pertussis toxin vaccines were compared between ART experienced HIV+ children (n=64) aged 5-10 years, and their age- and sex-matched HIV- controls (n=47). Prevalence of high-density lipoprotein cholesterol (HDL-c) and triglyceride-driven dyslipidemia was higher among treated HIV+ children than in controls (51.6% vs 27.7% respectively, p < 0.019). In a multivariate Poisson regression model adjusted for age, sex and BMI, the association between low HDL-c, hypertriglyceridemia and HIV remained significantly high (for HDL-c: ARR: 0.89, 95% CI: 0.82 – 0.96, p = 0.003; for triglycerides: ARR: 1.54, 95% CI: 1.31 – 1.81, p < 0.001). Among HIV+ children, the use of lopinavir/ritonavir, a protease-based antiretroviral therapy was also associated elevation of triglyceride levels (p = 0.032). Also, HIV+ children had a 2.8-fold reduction of anti-measles IgG titers and 17.1-fold reduction of anti-pertussis toxin IgG levels when compared to HIV- children. Our findings suggest that dyslipidemia and inadequate vaccine-induced antibody responses observed in this population of young African HIV+ children might increase their risk for premature onset of cardiovascular illnesses and acquisition of preventable diseases.en_US
dc.description.sponsorshipThis work was supported by the University of Dar es Salaam (MCHAS-20022) and by Network Funds (PLAY HIGH and UAW project grants) from Ludwig Maximilians University of Munich (LMU)-Center for International Health (CIH), through DAAD/Exceed Program which is funded by the Ministry of Economic Efforts and Development of Germany (BMZ)en_US
dc.identifier.citationMbuya Wilbert, Mwakyula Issakwisa, Olomi Willyelimina, Agrea Peter, Nicoli Francesco, Ngatunga Cecilia, Mujwahuzi Leodegard, Mwanyika Paul, Chachage Mkunde(2021) Altered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in Tanzania. Front. Cell. Infect. Microbiol. 11:721747. doi: 10.3389/fcimb.2021.721747en_US
dc.identifier.issn2235-2988
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5907
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.subjectHIV, children, dyslipidemia, cardiovascular disease, immune senescence, childhood vaccines, ARTen_US
dc.titleAltered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in Tanzaniaen_US
dc.title.alternativeDyslipidemia in HIV+ART+ Childrenen_US
dc.typeJournal Article, Peer Revieweden_US
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