ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons

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dc.contributor.authorBorasio, Gian D.
dc.contributor.authorJohn, Jasson
dc.contributor.authorWittinghofer, Alfred
dc.contributor.authorBarde, Y. A.
dc.contributor.authorSendtner, Michael
dc.contributor.authorHeumann, Rolf
dc.date.accessioned2016-07-14T20:55:21Z
dc.date.available2016-07-14T20:55:21Z
dc.date.issued2009-01
dc.descriptionFull text can be accessed at http://www.sciencedirect.com/science/article/pii/089662738990233Xen_US
dc.description.abstractAlthough evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the neuronal response to neurotrophic factors in nontransformed cells. We report here that the oncogene protein T24-ras, when introduced into the cytoplasm of freshly dissociated chick embryonic neurons, promotes the in vitro survival and neurite outgrowth of nerve growth factor-responsive dorsal rootganglion neurons, brain-derived neurotrophic factor-responsive nodose ganglion neurons, and ciliary neuronotrophic factor-responsive ciliary ganglion neurons. The proto-oncogene product c-Ha-ras also promotes neuronal survival, albeit less strongly. No effect could be observed with truncated counterparts of T24-ras and c-Ha-ras lacking the 23 C-terminal amino acids including the membrane-an-choring, palmityl-accepting cysteine. These results sug-gest a generalized involvement of ras or ras-like proteins in the intracellular signal transduction pathway for neurotrophic factors.en_US
dc.identifier.citationBorasio, G.D., John, J., Wittinghofer, A., Barde, Y.A., Sendtner, M. and Heumann, R., 1989. ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron, 2(1), pp.1087-1096.en_US
dc.identifier.doi10.1016/0896-6273(89)90233-X
dc.identifier.urihttp://hdl.handle.net/20.500.11810/3218
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.titleras p21 protein promotes survival and fiber outgrowth of cultured embryonic neuronsen_US
dc.typeJournal Articleen_US
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