Phytochemical Constituents of Vangueria Infausta: Their Radical Scavenging and Antimicrobial Activities
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Date
2007-01
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Abstract
A new biflavonoid, 5,7,3',5'',7'',4'''-hexahydroxy (4'-O-3''')-biflavone (1) and a polyketide derivative, methylcylohex-1-ene (3) [previously reported only as a synthetic compound] were isolated from aerial parts of Vangueria infausta. In addition, eight other known flavonoids viz. (-)-epicatechin, epiafzelechin, dihydrokaempferol, quercetin, luteolin (2), dihydroquercetin-3'-O-glucoside, daidzein and genistein were also isolated from this plant. Structures were identified using 1D-and 2D NMR experiments as well as ESI-MS, IR and UV spectra. The new biflavonoid 1 showed higher radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) reagent compared to ascorbic acid (standard) using a spectrophotometric method. Compound 1 was less sensitive to Gram-positive and Gram-negative bacterial strains and yeast (Candida mycoderma) compared to luteolin and quercetin on the Bioautographic Agar Overlay Assay.
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Keywords
Vangueria infausta, Flavonoids, Polyketide derivative, DPPH, Antibacterial, Antifungal
Citation
Mbukwa, E., Chacha, M. and Majinda, R.R., 2007. Phytochemical constituents of Vangueria infausta: their radical scavenging and antimicrobial activities. Arkivoc, 9, pp.104-112.