Polyoxygenated Cyclohexene Derivatives and Flavonoids from Uvaria pandensis Leaves

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dc.contributor.authorGasper, Maeda
dc.contributor.authorPieter, J. Gilissen
dc.contributor.authorCatarina, Bourgard
dc.contributor.authorJelle, van der Wal
dc.contributor.authorJoan, J. E. Munissi
dc.contributor.authorStephen, S. Nyandoro
dc.contributor.authorMáté, Erdélyi
dc.date.accessioned2024-06-19T22:13:56Z
dc.date.available2024-06-19T22:13:56Z
dc.date.issued2022-04
dc.description.abstractAbstract Three new oxygenated cyclohexene derivatives, pandensenol D - F (1–3), two new flavanoids, pandensone A and B (4–5), and seven known compounds (6–12) were isolated from the methanol extract of the leaves of Uvaria pandensis Verdc. (Annonaceae). The structures were characterized by NMR spectroscopic and mass spectrometric analyses. The isolated metabolites were evaluated for their antibacterial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis, the Gram-negative bacteria Enterococcus raffinosus, Escherichia coli, Paraburkholderia caledonica, Pectobacterium carotovorum and Pseudomonas putida, and for cytotoxicity against the MCF-7 human breast cancer cell line. Out of the tested compounds, pandensenol D (1) and (6′,7′-dihydro-8'α,9'β-dihydroxy)-3-farnesylindole (12) showed weak activity, whereas (8'α,9'β-dihydroxy)-3-farnesylindole (11) strong activity against B. subtilis. Four of the isolated compounds (1, 4, 11 and 12) showed moderate cytotoxicity against MCF-7 breast cancer cells (EC50 > 100 μM).en_US
dc.description.sponsorshipSwedish Research Councilen_US
dc.identifier.citationGasper Maeda, Pieter J. Gilissen, Catarina Bourgard, Jelle van der Wal, Joan J. E. Munissi, Stephen S. Nyandoro, and Máté Erdélyi. Polyoxygenated Cyclohexene Derivatives and Flavonoids from Uvaria pandensis Leaves. Fitoterapia, 2022, Vol. 158, 105170 https://doi.org/10.1016/j.fitote.2022.105170en_US
dc.identifier.urihttps://doi.org/10.1016/j.fitote.2022.105170
dc.identifier.urihttps://repository.udsm.ac.tz/handle/123456789/6096
dc.publisherElsevieren_US
dc.subjectCyclohexene Derivativesen_US
dc.titlePolyoxygenated Cyclohexene Derivatives and Flavonoids from Uvaria pandensis Leavesen_US
dc.typeJournal Articleen_US
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