Heterocyclic Dithiocarbamato-Iron (III) Complexes: Single-Source Precursors for Aerosol-Assisted Chemical Vapour Deposition (AACVD) of Iron Sulfide Thin Films

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dc.contributor.authorMlowe, Sixberth
dc.contributor.authorLewis, David J.
dc.contributor.authorMalik, Mohammad A.
dc.contributor.authorRaftery, James
dc.contributor.authorMubofu, Egid B.
dc.contributor.authorO'Brien, Paul
dc.contributor.authorRevaprasadu, Neerish
dc.date.accessioned2016-06-15T20:49:33Z
dc.date.available2016-06-15T20:49:33Z
dc.date.issued2016
dc.description.abstractThe biomedical potential of flavonoids is normally restricted by their low water solubility. However, little has been reported on their encapsulation into polyamidoamine (PAMAM) dendrimers to improve their biomedical applications. Generation four (G4) PAMAM dendrimer containing ethylenediaminetetraacetic acid core with acrylic acid and ethylenediamine as repeating units was synthesized by divergent approach and used to encapsulate a flavonoid tetramethylscutellarein (TMScu, 1) to study its solubility and in vitro release for potential bioactivity enhancement. The as-synthesized dendrimer and the dendrimer–TMScu complex were characterized by spectroscopic and spectrometric techniques. The encapsulation of 1 into dendrimer was achieved by a co-precipitation method with the encapsulation efficiency of 77.8% ˘ 0.69% and a loading capacity of 6.2% ˘ 0.06%. A phase solubility diagram indicated an increased water solubility of 1 as a function of dendrimer concentration at pH 4.0 and 7.2. In vitro release of 1 from its dendrimer complex indicated high percentage release at pH 4.0. The stability study of the TMScu-dendrimer at 0, 27 and 40 ˝ C showed the formulations to be stable when stored in cool and dark conditions compared to those stored in light and warmer temperatures. Overall, PAMAM dendrimer-G4 is capable of encapsulating 1, increasing its solubility and thus could enhance its bioactivity.en_US
dc.identifier.citationMlowe, S., Lewis, D.J., Malik, M.A., Raftery, J., Mubofu, E.B., O'Brien, P. and Revaprasadu, N., 2016. Heterocyclic dithiocarbamato-iron (III) complexes: single-source precursors for aerosol-assisted chemical vapour deposition (AACVD) of iron sulfide thin films. Dalton Transactions.en_US
dc.identifier.doi10.1039/c5dt03881b
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2450
dc.language.isoenen_US
dc.titleHeterocyclic Dithiocarbamato-Iron (III) Complexes: Single-Source Precursors for Aerosol-Assisted Chemical Vapour Deposition (AACVD) of Iron Sulfide Thin Filmsen_US
dc.typeJournal Article, Peer Revieweden_US
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