Environmental concentrations of antibiotics impair zebrafish gut health.

Simple item page
dc.contributor.authorLi, Zhou
dc.contributor.authorSamwel Mchele Limbu
dc.contributor.authorFang, Qiao
dc.contributor.authorZhen-Yu, Du
dc.contributor.authorMeiling, Zhang
dc.date.accessioned2019-05-07T13:03:53Z
dc.date.available2019-05-07T13:03:53Z
dc.date.issued2018-01-04
dc.description.abstractAntibiotics have been widely used in human and veterinary medicine to both treat and prevent disease. Due to their high water solubility and low bioavailability, many antibiotic residues have been found in aquatic environments. Fish are an indispensable link between the environmental pollution and human health. However, the chronic effects of environmental concentrations of antibiotics in fish have not been thoroughly investigated. Sulfamethoxazole (SMX) and oxytetracycline (OTC) are frequently detected in aquatic environments. In this study, zebrafish were exposed to SMX (260 ng/L) and OTC (420 ng/L) for a six-week period. Results indicated that exposure to antibiotics did not influence weight gain of fish but increased the metabolic rate and caused higher mortality when treated fish were challenged with Aeromonas hydrophila. Furthermore, exposure to antibiotics in water resulted in a significant decrease in intestinal goblet cell numbers, alkaline phosphatase (AKP), acid phosphatase (ACP) activities, and the anti-oxidant response while there was a significant increase in expression of inflammatory factors. Antibiotic exposure also disturbed the intestinal microbiota in the OTC-exposed group. Our results indicated that environmental antibiotic concentrations can impair the gut health of zebrafish. The potential health risk of antibiotic residues in water should be evaluated in the future.en_US
dc.description.sponsorshipThe National Natural Science Foundation of China [grant number 31672668]; the Science and Technology Commission of Shanghai Municipality [grant number 16ZR1409900]; and open funding project of the key laboratory of exploration and utilization of aquatic genetic resourcesen_US
dc.identifier.doihttps://doi.org/10.1016/j.envpol.2017.12.073
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5218
dc.publisherElsevieren_US
dc.subjectAntibioticen_US
dc.subjectIntestinal microbiotaen_US
dc.subjectGut healthen_US
dc.subjectZebrafishen_US
dc.titleEnvironmental concentrations of antibiotics impair zebrafish gut health.en_US
dc.typeJournal Article, Peer Revieweden_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Environmental concentrations of antibiotics impair zebrafish gut health.pdf
Size:
2.19 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Department of Aquatic Sciences and Fisheries Technology