The comparisons in protective mechanisms and efficiencies among dietary α-lipoic acid, β-glucan and L-carnitine on Nile tilapia infected by Aeromonas hydrophila

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dc.contributor.authorLu, Dong-Liang
dc.contributor.authorSamwel Mchele Limbu
dc.contributor.authorHong-Bo, Lv
dc.contributor.authorMa, Qiang
dc.contributor.authorChen, Li-Qiao
dc.contributor.authorZhang, Mei-Ling
dc.contributor.authorDu, Zhen-Yu
dc.date.accessioned2019-05-07T15:22:40Z
dc.date.available2019-05-07T15:22:40Z
dc.date.issued2018-12-13
dc.description.abstractDietary α-lipoic acid (LA), β-glucan (Gluc) and l-carnitine (L-Ca) are commonly used additives to promote fish growth and stress resistance in aquaculture production. However their mechanisms and efficiencies in helping fish to resist diseases have not been compared before. In this study, we fed Nile tilapia (Oreochromis niloticus) with diets containing appropriate doses of LA, Gluc and L-Ca for five weeks and further intraperitoneally injected the fish with Aeromonas hydrophila. After dietary treatment, none of the additives affected the fish growth, but dietary Gluc and L-Ca reduced protein and lipid body contents in fish, respectively. After A. hydrophila challenge, all fish treated with the three dietary additives showed higher survival rate, but those fed on dietary L-Ca had lower survival than those fed on LA and Gluc diets, indicating high protection efficiency of LA and Gluc. The protective mechanisms of the three feed additives were quite different under A. hydrophila infection. Dietary LA induced higher total antioxidant capacity and higher mRNA expression of anti-oxidative genes than other additives in liver and also activated partly the immune function in serum and spleen. Gluc largely increased the immune function by activating the immunity enzymes in serum, inducing inflammation in liver and increasing the expression of immune genes in spleen and head kidney. Gluc also increased partly the antioxidant capacity in serum and liver and lipid catabolism in liver. L-Ca largely increased lipid catabolism in liver while it increased partly the antioxidant capacities in serum and liver. Taken together, these results indicate that, dietary LA, Gluc and L-Ca have various protective mechanisms and differ in their efficiencies on resisting A. hydrophila infection in Nile tilapia.en_US
dc.description.sponsorshipThe National Natural Science Foundation of China (grant number 31472290 and 31772859).en_US
dc.identifier.doihttps://doi.org/10.1016/j.fsi.2018.12.023
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5231
dc.publisherElsevieren_US
dc.subjectNile tilapiaen_US
dc.subjectPathogen resistanceen_US
dc.subjectα-lipoic aciden_US
dc.subjectβ-glucanen_US
dc.subjectl-carnitineen_US
dc.subjectDietary additivesen_US
dc.titleThe comparisons in protective mechanisms and efficiencies among dietary α-lipoic acid, β-glucan and L-carnitine on Nile tilapia infected by Aeromonas hydrophilaen_US
dc.typeJournal Article, Peer Revieweden_US
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