Medicinal Potential of Melodorum Gracile and Mkilua Fragrans Extracts

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dc.contributor.authorLyantagaye, Sylvester L.
dc.date.accessioned2016-05-05T14:04:42Z
dc.date.available2016-05-05T14:04:42Z
dc.date.issued2014-02-27
dc.description.abstractCrude ethanol extracts of Melodorum gracile and Mkilua fragrans were screened for antimicrobial activity against Streptococcus agalactiae, Staphylococcus aureus, Salmonella gallinarum and Escherichia coli of veterinary importance. Agar diffusion technique was used to determine the inhibition of microbial growth and broth dilution technique was used to determine MIC and MBC. The crude extracts exhibited predominantly antibacterial activity with the root extract showing the strongest inhibition against the test bacteria at a MIC of between 7 µg/ml and 500 µg/ml. The study has shown that Mkilua fragrans extract is very potent against Streptococcus agalactiae and Staphylococcus aureus but no effect against Salmonella gallinarum and Escherichia coli. The study also showed that Melodonium gracile extracts were potent against Streptococcus agalactiae, Staphylococcus aureus, Salmonella gallinarum and Escherichia coli. Most of the plant extracts were significantly lethal towards brine shrimps. This is the first scientific evaluation of the veterinary medicinal potential of the Melodorum gracile and Mkilua fragrans indigenous to Tanzania, providing the baseline for further investigations on the plants towards new drug discovery.en_US
dc.identifier.citationLyantagaye, S.L., 2014. Medicinal potential of Melodorum gracile and Mkilua fragrans extracts. Journal of Applied Pharmaceutical Science, 4(2), p.8.en_US
dc.identifier.doi10.7324/JAPS.2014.40202
dc.identifier.issn2231-3354
dc.identifier.urihttp://hdl.handle.net/20.500.11810/1819
dc.language.isoenen_US
dc.subjectAntimicrobial activityen_US
dc.subjectMelodorum gracileen_US
dc.subjectMkilua fragransen_US
dc.subjectTanzaniaen_US
dc.subjectVeterinaryen_US
dc.titleMedicinal Potential of Melodorum Gracile and Mkilua Fragrans Extractsen_US
dc.typeJournal Article, Peer Revieweden_US
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