The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density

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dc.contributor.authorSlater, Hannah
dc.contributor.authorRoss, Amanda
dc.contributor.authorFelger, Ingrid
dc.contributor.authorHofmann, Natalie
dc.contributor.authorRobison, Leanne
dc.contributor.authorcook, Jackie
dc.contributor.authorGonçalves, Bronner
dc.contributor.authorBjòrkman, Andes
dc.contributor.authorOuedraogo, Andre
dc.contributor.authorMorris, Ulrika
dc.contributor.authorMsellem, Mwinyi
dc.contributor.authorKoepfli, Christian
dc.contributor.authorMuller, Ivo
dc.contributor.authorTadesse, Fitsum
dc.contributor.authorGadisa, Endalamaw
dc.contributor.authorDas, Simita
dc.contributor.authorDomingo, Gonzalo
dc.contributor.authorKapulu, Melissa
dc.contributor.authorMidega, Janet
dc.contributor.authorOwusu-Agyei, Seth
dc.contributor.authorNabet, Cecile
dc.contributor.authorPiarroux, Renaud
dc.contributor.authorDuombo, Ogobara
dc.contributor.authorNiare, Safiatou
dc.contributor.authorkoram, Kwadwo
dc.contributor.authorLucci, Nami
dc.contributor.authorUdhayakumar, Venkatachalam
dc.contributor.authorMosha, Jackline
dc.contributor.authorTiono, Alfred
dc.contributor.authorChandramohan, Daniel
dc.contributor.authorGosling, Roly
dc.contributor.authorMwingira, Felista
dc.contributor.authorSauerwein, Robert
dc.contributor.authorPaul, Richard
dc.contributor.authorRiley, Eleanor
dc.contributor.authorWhite, Nicholas
dc.contributor.authorNosten, Francois
dc.contributor.authorImwong, Mallika
dc.contributor.authorBousema, Teun
dc.contributor.authorDrakeley, Chris
dc.contributor.authorOkell, Lucy
dc.date.accessioned2020-08-31T09:43:05Z
dc.date.available2020-08-31T09:43:05Z
dc.date.issued2019-03-29
dc.description.abstractMalaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings.en_US
dc.identifier.citationSlater, H.C., Ross, A., Felger, I. et al. Author Correction: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density. Nat Commun 10, 2644 (2019). https://doi.org/10.1038/s41467-019-10790-0en_US
dc.identifier.doihttps://doi.org/10.1038/s41467-019-10790-0
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5486
dc.language.isoenen_US
dc.publisherNature Communicationsen_US
dc.relation.ispartofseries10;2644
dc.subjectMalaria, Plasmodium falciparumen_US
dc.titleThe temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite densityen_US
dc.typeJournal Article, Peer Revieweden_US
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