Dietary sodium acetate improves high-fat diet utilization through promoting differential nutrients metabolism between liver and muscle in Nile tilapia (Oreochromis niloticus)

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dc.contributor.authorWen-Hao Zhou
dc.contributor.authorSamwel Mchele Limbu
dc.contributor.authorRui-Xin Li
dc.contributor.authorYuan Luo
dc.contributor.authorJiong Ren
dc.contributor.authorFang Qiao
dc.contributor.authorMei-Ling Zhang
dc.contributor.authorZhen-Yu Du
dc.date.accessioned2023-04-14T15:08:50Z
dc.date.available2023-04-14T15:08:50Z
dc.date.issued2023-02-25
dc.description.abstractigh-fat diet (HFD) often causes many negative effects and impairs fish growth. Short-chain fatty acids (SCFAs) such as acetates modify metabolic disorders and regulate body homeostasis. However, the effects of sodium acetate on alleviating HFD in fish is currently unknown. This study investigated the role of using dietary sodium acetate to alleviate adverse effects caused by HFD in fish. Three replicates (thirty fish each) of 4.8 ± 0.30 g Nile tilapia (Oreochromis niloticus) were fed with control diet (Con), high-fat diet (HFD) or HFD containing sodium acetate diet (HFD + NaAc) for eight weeks. After the feeding trial, Nile tilapia fed with HFD increased significantly tissue lipid deposition, reduced insulin sensitivity and suppressed glucose and lipid metabolism in both liver and muscle, accompanied with signs of metabolic disorders and liver damage. Moreover, HFD feeding inhibited muscle protein synthesis and impaired fish growth performance. However, the fish fed on HFD + NaAc improved significantly oxidative stress, inflammation, apoptosis and injury in liver compared to those fed on HFD. More importantly, dietary sodium acetate supplementation enhanced insulin sensitivity, promoted glucose catabolic utilization and protein synthesis in muscle through activation of insulin and mTOR signaling pathways, respectively, and markedly improved the growth performance. In contrast, dietary sodium acetate promoted hepatic pentose phosphate pathway, hepatic glycogen accumulation, and activated lipid catabolism to alleviate hepatic lipid deposition. Our study illustrates that sodium acetate alleviates differentially the adverse effects induced by feeding Nile tilapia with HFD in muscle and liver. SCFAs such as acetate may be used for improving HFD utilization in fish nutrition.en_US
dc.description.sponsorshipNational Key Research and Development Program of China (2018YFD0900400)en_US
dc.identifier.citationWen-Hao Zhou, Samwel M. Limbu, Rui-Xin Li, Yuan Luo, Jiong Ren, Fang Qiao, Mei-Ling Zhang and Zhen-Yu Du (2023). Dietary sodium acetate improves high-fat diet utilization through promoting differential nutrients metabolism between liver and muscle in Nile tilapia (Oreochromis niloticus). Aquaculture, 565: 739142. https://doi.org/10.1016/j.aquaculture.2022.739142.en_US
dc.identifier.doihttps://doi.org/10.1016/j.aquaculture.2022.739142
dc.identifier.urihttp://hdl.handle.net/20.500.11810/6036
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectHigh-fat dieten_US
dc.subjectSodium acetateen_US
dc.subjectMetabolic disordersen_US
dc.subjectLiver healthen_US
dc.subjectNile tilapiaen_US
dc.titleDietary sodium acetate improves high-fat diet utilization through promoting differential nutrients metabolism between liver and muscle in Nile tilapia (Oreochromis niloticus)en_US
dc.typeJournal Article, Peer Revieweden_US
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