Environmental estrogen exposure converts lipid metabolism in male fish to a female pattern mediated by AMPK and mTOR signaling pathways. Journal of Hazardous Materials, 394: 122537.

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dc.contributor.authorSheng-Xiang Sun
dc.contributor.authorJun-Lin Wu
dc.contributor.authorHong-Bo Lv
dc.contributor.authorHai-Yang Zhang
dc.contributor.authorJing Zhang
dc.contributor.authorSamwel Mchele Limbu
dc.contributor.authorFang Qiao
dc.contributor.authorLi-Qiao Chen
dc.contributor.authorYi Yang
dc.contributor.authorMei-Ling Zhang
dc.contributor.authorZhenyu Du
dc.date.accessioned2021-04-18T06:21:21Z
dc.date.available2021-04-18T06:21:21Z
dc.date.issued2020-07-15
dc.description.abstractEnvironmental estrogens, including bisphenol A (BPA) and 17β-estradiol (E2), which are widely used in industries and medicine, pose a severe ecological threat to fish due to feminization induction. However, the related metabolic basis for reproductive feminization in male fish has not been well addressed. We first found that female zebrafish exhibited higher lipid accumulation and lipogenesis activity than males. Next, we exposed male and female zebrafish to E2 (200 ng/L) or BPA (100 μg/L) for six weeks, and observed an early-phase reproductive feminization in males, accompanied with reduced spermatids, significant fat deposition and lipogenic gene expressions that mimicked female patterns. Cellular signaling assays revealed that, E2 or BPA modulated lipid metabolism in males mainly through lowering 5′ AMP-activated protein kinase (AMPK) and upregulating the lipogenic mechanistic target of rapamycin (mTOR) pathways. For the first time, we show that environmental estrogens could alter lipid metabolism in male fish to a female pattern (metabolic feminization) prior to gonad feminization in male fish, to allows males to accumulate efficiently lipids to harmonize with the feminized gonads. This study suggests that negative effects of environmental estrogens, as hazardous materials, on vertebrate health are more complicated than originally thought.en_US
dc.description.sponsorshipNational Key Research and Development Program of China (2018YFD0900400) and National Natural Science Fund (31830102).en_US
dc.identifier.citationSheng-Xiang Sun, Jun-Lin Wu, Hong-Bo Lv, Hai-Yang Zhang, Jing Zhang, Samwel Mchele Limbu, Fang Qiao, Li-Qiao Chen, Yi Yang, Mei-Ling Zhang and Zhenyu Du (2020). Environmental estrogen exposure converts lipid metabolism in male fish to a female pattern mediated by AMPK and mTOR signaling pathways. Journal of Hazardous Materials, 394: 122537. https://doi.org/10.1016/j.jhazmat.2020.122537.en_US
dc.identifier.doihttps://doi.org/10.1016/j.jhazmat.2020.122537.
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5613
dc.publisherElsevieren_US
dc.subjectEnvironmental estrogens; 17β-estradiol (E2); Bisphenol A (BPA); Lipid metabolism; Feminizationen_US
dc.titleEnvironmental estrogen exposure converts lipid metabolism in male fish to a female pattern mediated by AMPK and mTOR signaling pathways. Journal of Hazardous Materials, 394: 122537.en_US
dc.typeJournal Article, Peer Revieweden_US
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