Inhibited fatty acid β-oxidation impairs stress resistance ability in Nile tilapia (Oreochromis niloticus)., 68: 500-508.

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dc.contributor.authorHan, Pan
dc.contributor.authorLing-Yu, Li
dc.contributor.authorJia-Min, Li
dc.contributor.authorWei-Li, Wang
dc.contributor.authorSamwel Mchele Limbu
dc.contributor.authorPascal, Degrace
dc.contributor.authorDong-Liang, Li
dc.contributor.authorZhen-Yu, Du
dc.date.accessioned2019-05-07T13:03:11Z
dc.date.available2019-05-07T13:03:11Z
dc.date.issued2017-07-31
dc.description.abstractEnergy metabolism plays important roles in stress resistance and immunity in mammals, however, such functions have not been established in fish. In the present study, Nile tilapia (Oreochromis niloticus) was fed with mildronate, an inhibitor of mitochondrial fatty acid (FA) β-oxidation, for six weeks subsequently challenged with Aeromonas hydrophila and ammonia nitrogen exposure. Mildronate treatment reduced significantly l-carnitine concentration and mitochondrial FA β-oxidation efficiency, while it increased lipid accumulation in liver. The fish with inhibited hepatic FA catabolism had lower survival rate when exposed to Aeromonas hydrophila and ammonia nitrogen. Moreover, fish fed mildronate supplemented diet had lower immune enzymes activities and anti-inflammatory cytokine genes expressions, but had higher pro-inflammatory cytokine genes expressions. However, the oxidative stress-related biochemical indexes were not significantly affected by mildronate treatment. Taken together, inhibited mitochondrial FA β-oxidation impaired stress resistance ability in Nile tilapia mainly through inhibiting immune functions and triggering inflammation. This is the first study showing the regulatory effects of lipid catabolism on stress resistance and immune functions in fish.en_US
dc.description.sponsorshipNational Basic Research Program of China (973 program 2014CB138603) and National Natural Science Fund (31472290).en_US
dc.identifier.doihttps://doi.org/10.1016/j.fsi.2017.07.058
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5215
dc.publisherElsevieren_US
dc.subjectNile tilapiaen_US
dc.subjectl-carnitineen_US
dc.subjectMildronateen_US
dc.subjectFatty acid β-oxidationen_US
dc.subjectStress resistanceen_US
dc.subjectImmune functionen_US
dc.titleInhibited fatty acid β-oxidation impairs stress resistance ability in Nile tilapia (Oreochromis niloticus)., 68: 500-508.en_US
dc.typeJournal Article, Peer Revieweden_US
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