Bioactivities of extracts, debromolaurenterol and fucosterol from macroalgae species

dc.contributor.authorBegum, Sartaz
dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorBuriyo, Amelia S.
dc.contributor.authorMakangara, John J
dc.contributor.authorMunissi, Joan J.E
dc.contributor.authorDuffy, Sandra
dc.contributor.authorAvery, Vicky M.
dc.contributor.authorErdelyi, Mate
dc.date.accessioned2018-11-08T10:09:32Z
dc.date.available2018-11-08T10:09:32Z
dc.date.issued2018-06
dc.description.abstractParasitic diseases including malaria, and other numerous microbial infections and physiological diseases are threatening the global population. Tanzanian coast shores are endowed with a variety of macroalgae (seaweeds), hitherto unsystematically explored to establish their biomedical potentials. Thus, antiplasmodial activity using malarial imaging assay, antimicrobial activity using microplate dilution technique, antioxidant activity using DPPH radical scavenging method and cytotoxicity using brine shrimp test were carried out on crude extracts from the selected species of algae (Acanthophora spicifera, Cystoseira myrica, Cystoseira trinodis, Laurencia filiformis, Padina boryana, Sargassum oligocystum, Turbinaria crateriformis, Ulva fasciata and Ulva reticulata) occurring along the coast of Tanzania. The extracts showed antimicrobial activities with MIC ranging from 0.3- 5.0 μg/mL against Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Cryptococcus neoformans; DPPH radical scavenging activity at EC50 1.0- 100 μg/mL and cytotoxicity on brine shrimp larvae with LC50 value ranging from20 - 1000 μg/mL. The extracts from C. myrica and P. boryana inhibited growth of Plasmodium falciparum (3D7 strain) by 80 and 71%, respectively at 40 μg/mL while a sesquiterpene debromolaurinterol (1) which was chromatographically isolated from C. myrica exhibited antiplasmodial activity with IC50 20 μM whereas a sterol fucosterol (2) from P. boryana showed weak activity at 40 μM. Bioactivities portrayed by the investigated extracts indicate their ingredients as potential sources of bioactive agents that warrant further explorations.en_US
dc.identifier.citationSartaz Begum, Stephen S. Nyandoro, Amelia S. Buriyo, John J. Makangara, Joan J.E. Munissi, Sandra Duffy, Vicky M. Avery and Mate Erdelyi, Bioactivities of extracts, debromolaurenterol and fucosterol from macroalgae species, Tanzania Journal of Science. 2018, 44 (2), 104 - 116en_US
dc.identifier.issn0856-1761
dc.identifier.urihttp://hdl.handle.net/20.500.11810/4964
dc.language.isoenen_US
dc.publisherDar es Salaam University Pressen_US
dc.subjectMacrolgae, antiplasmodial, antimicrobial, antioxidant, cytotoxicity, DPPH radical scavenging, debromolaurinterol and fucosterolen_US
dc.titleBioactivities of extracts, debromolaurenterol and fucosterol from macroalgae speciesen_US
dc.typeJournal Articleen_US
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