Effects of α‐lipoic acid on growth performance, body composition, antioxidant profile and lipid metabolism of the GIFT tilapia (Oreochromis niloticus) fed high-fat diets.

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dc.contributor.authorXu, Fangning
dc.contributor.authorXu, Chang
dc.contributor.authorXiao, Shusheng
dc.contributor.authorLu, Maixin
dc.contributor.authorSamwel Mchele Limbu
dc.contributor.authorWang, Xiaodan
dc.contributor.authorDu, Zhen-Yu
dc.contributor.authorQin, Jian G.
dc.contributor.authorChen, Li-Qiao
dc.date.accessioned2019-05-08T05:40:37Z
dc.date.available2019-05-08T05:40:37Z
dc.date.issued2019-01-18
dc.description.abstractThe wide use of lipid as a non‐protein energy substitute has led to lipid metabolic problems in cultured tilapia. Therefore, studies that reduce the effects of high‐fat diets in genetically improved farmed tilapia (GIFT) are required. This study evaluated the optimum level and effects of dietary α‐lipoic acid (α‐LA) on growth performance, body composition, antioxidant capacity and lipid metabolism of GIFT tilapia. The basal diet (120 g/kg lipid) was supplemented with six concentrations of α‐LA at 0 (control), L300, L600, L900, L1200 and L2400 mg/kg diet to make the experimental diets, which were fed to GIFT tilapia juveniles (initial body weight: 0.48 ± 0.01 g) for 8 weeks. The weight gain of fish improved significantly in the L300 than other dietary treatments. The intraperitoneal fat index and lipid content of fish fed on the L2400 diet decreased significantly than those fed on the control diet. The activities of superoxide dismutase and glutathione peroxidase (GSH‐Px) in serum and liver were significantly higher in fish fed on the L300 diet than the control. The reduced GSH content of fish fed on the L300 in serum and liver was significantly higher than those fed on control diet. The malondialdehyde content in serum and liver was significantly lower in L300 than in the control. The adipose triglyceride lipase gene was significantly up‐regulated in fish fed on the L2400, but the diacylglycerol acyltransferase 2 gene was down‐regulated in adipose. The liver‐type fatty acid‐binding protein gene in the liver was significantly up‐regulated in fish fed on the L300 and L600 diets. Moreover, the acyl‐coenzyme A oxidase gene in liver was significantly up‐regulated in fish fed on the L300, L600, L900 and L1200 diets. Polynomial regression analysis indicated that 439–528 mg/kg α‐LA is an appropriate dosage in high‐fat diet to improve growth performance and relieve lipid oxidative damage by accelerating lipid catabolism and reducing lipid synthesis in GIFT tilapia.en_US
dc.description.sponsorshipThe Major State Basic Research Development Program of China (973 Program) (No. 2014CB138600) and China Agriculture Research System‐46 (CARS‐46).en_US
dc.identifier.doihttps://doi.org/10.1111/anu.12881
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5236
dc.publisherAquaculture Nutritionen_US
dc.subjectantioxidant statusen_US
dc.subjectgrowth performanceen_US
dc.subjecthigh‐fat dieten_US
dc.subjectlipid metabolismen_US
dc.subjectOreochromis niloticusen_US
dc.subjectα‐lipoic aciden_US
dc.titleEffects of α‐lipoic acid on growth performance, body composition, antioxidant profile and lipid metabolism of the GIFT tilapia (Oreochromis niloticus) fed high-fat diets.en_US
dc.typeJournal Article, Peer Revieweden_US
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