Browsing by Author "Sakurai, Hiroaki"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
Item Iodine-Catalyzed Etherification of Morroniside(2009-09) Sunghwa, Fortunatus; Sakurai, Hiroaki; Saiki, Ikuo; Koketsu, MamoruIn this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 μM.