Browsing by Author "Choi, Andy H."

Now showing 1 - 6 of 6
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    Advances in Bioglass and Glass Ceramics for Biomedical Applications
    (Wiley, 2016-05) Ben-Nissan, Besim; Choi, Andy H.; Macha, Innocent J
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    Advances in Calcium Phosphate Nanocoatings and Nanocomposites
    (Springer, 2013-12) Choi, Andy H.; Ben-Nissan, Besim; Conway, Richard C.; Macha, Innocent J
    It is possible by using nanocomposite approach to control the strength and Young’s modulus of the composite to become close to those of human cortical or cancellous bone. This is made possible with the help of secondary substitution phases. Various materials have been applied as biomaterials and tissue regeneration materials, and the in vivo cytotoxicity and biocompatibility have been the main consideration in their use and their long-term success. This chapter aims to give a brief introduction and current applications of calcium phosphate nanocomposites as tissue engineering and as a delivery vehicle for drugs, genes, and proteins. Furthermore, the chapter will also examine the potential use of calcium phosphate nanocomposite coatings for tissue engineering scaffolds.
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    Calcium phosphate nanocoatings and nanocomposites, part 2: thin films for slow drug delivery and osteomyelitis
    (Future Medicine, 2016-02-19) Ben-Nissan, Besim; Macha, Innocent J; Cazalbou, Sophie; Choi, Andy H.
    During the last two decades although many calcium phosphate based nanomaterials have been proposed for both drug delivery, and bone regeneration, their coating applications have been somehow slow due to the problems related to their complicated synthesis methods. In order to control the efficiency of local drug delivery of a biomaterial the critical pore sizes as well as good control of the chemical composition is pertinent. A variety of calcium phosphate based nanocoated composite drug delivery systems are currently being investigated. This review aims to give an update into the advancements of calcium phosphate nanocoatings and thin film nanolaminates. In particular recent research on PLA/hydroxyapatite composite thin films and coatings into the slow drug delivery for the possible treatment of osteomyelitis is covered.
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    Development and In Vitro Analysis of a New Biodegradable PLA/Hydroxyapatite (HAp) Composite for Biomedical Applications
    (2017-06-08) Macha, Innocent J; Ben-Nissan, Besim; Choi, Andy H.; Cazalbou, Sophie
    The development of new drugs or formulations for the treatments of different musculoskeletal disorders (MSDs) has now being a focus of pharmaceutical and scientific societies. Targeted and multidelivery of drug and key minerals to support bone repair and regeneration at the defect site, from flexible biodegradable devices at the rate within the therapeutic window, seem to be an effective strategy. However, the drug delivery vehicles available are neither flexible and degradable nor able to deliver both pharmaceutical drug and minerals effectively. The use of biodegradable polymer and bioceramic for composite development with enough flexibility and potential for slow in situ drug delivery for biomedical applications could be one of the real options to mitigate MSDs problem. In vitro analysis of the developed devices is a vital step towards clinical trial and commercialization of the implant. Different approach and results have been compared to draw guidelines for the development and testing of thin film composite applications as a slow drug delivery vehicle.
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    Nanostructured Calcium Phosphates for Drug, Gene, DNA and Protein Delivery and as Anticancer Chemotherapeutic Devices
    (2017-06-08) Choi, Andy H.; Macha, Innocent J; Akyol, Sibel; Cazalbou, Sophie; Ben-Nissan, Besim
    During the past two decades, a number of materials and devices have been utilised in drug delivery applications. A range of biomaterials with different morphologies and pore sizes are currently utilised. For any given biomaterial or bioceramic, having an adequate control of the chemical composition as well as the critical pore sizes is important in terms of controlling the effectiveness when used to deliver drugs locally. In comparison to all currently known and used biomaterials, given the fact that it possesses chemical similarity to human bone, and most importantly its dissolution characteristics which allow for bone regeneration and growth, calcium phosphate holds a special consideration. Moreover, due to their interconnected pore structure, marine materials such as shells and coral exoskeletons show potential for applications in drug delivery due to their easy conversion to calcium phosphates with controllable dissolution rates. This chapter covers a range of current methods used specifically for natural materials that can be converted to calcium phosphates and mixed with polymeric materials as thin film or nanostructured drug, genes, protein and range of delivery and as anticancer chemotherapeutic devices.
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    Sol-Gel Nanocoatings of Bioceramics
    (Springer, 2014-12) Ben-Nissan, Besim; Choi, Andy H.; Macha, Innocent J; Cazalbou, Sophie
    The ability to produce homogeneous high-purity materials is of great interest to industrial and medical applications. In addition, the chemical and physical changes observed at the nanoscale and their influence on properties have been an important academic interest. The gel-structure transition plays a critical role in the formation as well as the current production of various types of sol-gel-derived materials such as nanopowders, nanofibers, nanocoatings, nanocomposites, and solid monoliths. It is the area of thin film coatings produced by sol-gel technology that this chapter covers. In particular, this chapter focuses on the basic synthesis and application methods to produce nanocoatings for biomedical applications. This chapter also attempts to answer some of the pertinent questions related to sol-gel processing and production methods and issues related to the fundamental understanding of the sol-gel process.