Browsing by Author "Borkner, Lisa"

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    Immune Protection against Virus Challenge in Aging Mice Is Not Affected By Latent Herpesviral Infections
    (2015-09) Marandu, Thomas F.; Oduro, Jennifer D.; Borkner, Lisa; Dekhtiarenko, Iryna; Uhrlaub, Jennifer; Drabig, Anja; Kröger, Andrea; Zugich, Janko N.; Sain, Luka C.
    Latent herpesvirus infections alter the immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse CMV, HSV-1 and/or MHV-68 with Influenza, WNV or VSV. We observed no increase in mortality or weight-loss over herpesvirus-negative counterparts and a relative, but no absolute reduction in CD8 responses against acute infections. Therefore, herpesviruses do not appear to increase susceptibility to emerging infections in aging. Copyright © 2015, American Society for Microbiology. All Rights Reserved