Sunghwa, FortunatusSakurai, HiroakiSaiki, IkuoKoketsu, Mamoru2016-07-212016-07-212009-09Sunghwa, F., Sakurai, H., Saiki, I. and Koketsu, M., 2009. Iodine-catalyzed etherification of morroniside. Chemical and Pharmaceutical Bulletin, 57(1), pp.112-115.http://hdl.handle.net/20.500.11810/3371Full text can be accessed at https://www.jstage.jst.go.jp/article/cpb/57/1/57_1_112/_pdfIn this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 μM.enetherificationMorronisideCytotoxicityJournal Article10.1002/chin.200936185